- Wednesday, April 5, 2023
AMETEK Gatan provides the camera technology leading the way in developing effective virus treatments
Providing new insight into virus structure
Single-particle cryo-electron microscopy (cryo-EM) is an increasingly popular technique structural biologists use to solve structures at atomic resolution. It has become an essential tool for medical researchers and has played a vital role in solving the 3D structure of viruses. Cryo-EM can solve molecular structures with a resolution below 1.5, a resolution level inconceivable just a few years ago. This structural insight has made possible the development and deployment of vaccines supporting life-saving health initiatives worldwide.
Revolutionary resolution delivers better results
AMETEK Gatan is the world’s leading manufacturer of instrumentation and software used to enhance and extend the operation and performance of electron microscopes. Its K3® camera is a true next-generation technology: A unique direct-detection camera that uses electron counting with super-resolution technology to record the image. The K3 is optimized for low-dose electron microscopy (EM) applications in life science and materials science research.
Capturing the detail needed for molecular study
Creating 3D atomic-scale maps of existing and newly discovered viruses is key to the rapid development of vaccines, therapeutic antibodies, and other medical countermeasures. Structural biologists frequently use cryo-EM to study viruses, but when conventional cameras for electron microscopy are used, a loss of high-resolution detail prevents cryo-EM from achieving its true potential. AMETEK Gatan technology uses breakthrough direct- detection technology to directly measure the electron image, avoiding detail loss from conventional camera image conversions.
Enabling the development of effective treatments
The K3 can map the spike protein of viruses – the area any virus uses to penetrate host cells, allowing it to replicate. With single- particle cryo-electron microscopy, researchers can determine the atomic structure of the spikes, helping to explain the virus’s resistance to antibodies used to disable similar illnesses. The K3 camera’s imaging performance prevents data collection from becoming a bottleneck, enabling more rapid determination of the structure and facilitating the swift development of vaccines and other treatments. Discover more about Gatan microscopy technologies at gatan.com
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